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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK8
All Species:
17.27
Human Site:
S280
Identified Species:
29.23
UniProt:
Q86SG6
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86SG6
NP_835464.1
692
74806
S280
R
M
R
R
A
E
K
S
V
A
P
S
N
T
G
Chimpanzee
Pan troglodytes
XP_511801
843
90571
S431
L
S
C
R
A
E
K
S
V
A
P
S
S
T
G
Rhesus Macaque
Macaca mulatta
XP_001106986
781
84378
S369
R
M
R
R
A
E
K
S
V
A
P
S
S
T
G
Dog
Lupus familis
XP_548291
727
78319
S308
R
M
R
R
A
E
K
S
L
V
P
G
P
P
M
Cat
Felis silvestris
Mouse
Mus musculus
Q91ZR4
698
75246
S280
R
M
R
R
A
E
K
S
L
T
P
G
P
P
I
Rat
Rattus norvegicus
NP_001099274
698
75236
C280
R
M
R
R
A
E
K
C
L
T
P
G
T
P
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512532
832
89432
W264
K
M
R
R
A
K
R
W
M
A
H
G
R
G
G
Chicken
Gallus gallus
XP_415822
728
79098
P280
K
M
R
R
P
E
K
P
L
A
P
V
Q
T
V
Frog
Xenopus laevis
Q7ZZC8
944
104521
N305
E
E
K
V
S
M
L
N
R
S
N
K
K
P
R
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
P280
K
M
R
R
I
E
K
P
L
S
N
V
Q
A
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_490968
998
111830
T456
D
L
H
V
P
T
I
T
L
S
S
I
P
D
L
Sea Urchin
Strong. purpuratus
XP_001201534
446
48490
S71
G
I
S
K
I
L
S
S
K
S
K
A
F
T
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
F231
P
A
Q
Y
S
A
A
F
R
G
L
V
K
S
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P48479
858
94329
R335
E
T
E
K
S
S
I
R
A
E
I
D
A
S
L
Conservation
Percent
Protein Identity:
100
75.4
87
88.8
N.A.
93.5
93.4
N.A.
68.7
76.9
24.7
73.8
N.A.
N.A.
N.A.
23.2
38.2
Protein Similarity:
100
76.9
87.8
91
N.A.
96.4
95.4
N.A.
74
85.1
39.5
85.2
N.A.
N.A.
N.A.
37.8
50.8
P-Site Identity:
100
73.3
93.3
60
N.A.
60
53.3
N.A.
40
53.3
0
40
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
80
100
66.6
N.A.
66.6
60
N.A.
66.6
66.6
26.6
60
N.A.
N.A.
N.A.
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.2
N.A.
21.7
Protein Similarity:
N.A.
N.A.
N.A.
44
N.A.
37.1
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
50
8
8
0
8
36
0
8
8
8
0
% A
% Cys:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% D
% Glu:
15
8
8
0
0
58
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
8
0
29
0
8
36
% G
% His:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
8
0
0
15
0
15
0
0
0
8
8
0
0
8
% I
% Lys:
22
0
8
15
0
8
58
0
8
0
8
8
15
0
0
% K
% Leu:
8
8
0
0
0
8
8
0
43
0
8
0
0
0
15
% L
% Met:
0
58
0
0
0
8
0
0
8
0
0
0
0
0
22
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
15
0
8
0
0
% N
% Pro:
8
0
0
0
15
0
0
15
0
0
50
0
22
29
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
15
0
0
% Q
% Arg:
36
0
58
65
0
0
8
8
15
0
0
0
8
0
8
% R
% Ser:
0
8
8
0
22
8
8
43
0
29
8
22
15
15
0
% S
% Thr:
0
8
0
0
0
8
0
8
0
15
0
0
8
36
0
% T
% Val:
0
0
0
15
0
0
0
0
22
8
0
22
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _